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The Metabolism of Cancer Survivorship

As advances in oncology contribute to a growing number of cancer survivors, the darker side of cancer therapies is becoming increasingly clear. Cancer survivors experience shortened life expectancy and suffer from inflammatory and fibrotic diseases at much higher rates compared to the general population. Our recent discoveries (Maus et al. Nature Metabolism, 2023) suggest a possible link between the adverse effects of cytotoxic therapies and iron accumulation. In this project, our goal is to shed light on how cancer therapy disrupts systemic and cellular iron homeostasis, how this is linked to cellular senescence, fibrosis and accelerated aging in individuals who underwent cytotoxic therapies. Our aim is to deliver novel diagnostics and therapeutics that can improve the lives of cancer survivors.

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